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Current Research Studies

Alcohol risk assessment using computerized alcohol screening instrument in trauma patients »

Principal Investigator: Shahram Lotfipour, MD, MPH

EMRAP Liaison(s): Tracy Nguyen

Purpose: To evaluate the alcohol consumption habits of trauma patients in the Emergency Department.

Ambulance diversion: a retrospective study »

Principal Investigator: Christopher McCoy, MD, MPH

Co-Investigator: Maxwell Jen, MD

EMRAP Liaison(s): Argineh Shahbandari, Mayuri Patel

Purpose: To analyze risk factors associated with ambulance diversion.

Andexanet alfa (annexa) potential reversal agent factor xa inhibitors: clinical trial study »

Principal Investigator: Shahram Lotfipour, MD, MPH

Co-Investigator: Rick Jones, CCRP

EMRAP Liaison(s): Leila Danishgar 

Purpose: To study the efficacy of Andexanet Alfa, a reversal anti-coagulant developed by Portola Pharmaceuticals. Specifically, we are looking at % change in anti-fXa activity, hemostatic efficacy in limited amount of time, and analyzing the relationship between decrease in anti-fXa and achievement of hemostatic efficacy

Clinical evaluation of tinnitus after head trauma in emergency setting. »

Principal Investigator: Yaser Ghavami, MD

EMRAP Liaison(s): Ryan Assaf

Purpose: The purpose of this research study is to determine the prevalence of acute and chronic tinnitus - the perception of sound without an external stimulus - in patients with a history of head trauma or traumatic brain injury. 

Comparative effectiveness of alcohol brief intervention providing by computer compared to trained person. »

Principal Investigator: Wirachin Hoonpongsimanont, MD

EMRAP Liaison(s): Leila Danishgar

Purpose: The purpose of this research study is to examine the effectiveness of computerized alcohol screening and brief intervention also known as the CASI program in the UC Irvine Medical Center Emergency Department (ED) for trauma and non-trauma patients comparing to in-person alcohol screening and brief intervention. CASI is a web-based computerized program designed to help identify at-risk or dependent alcohol drinkers, and provides resources to try to help improve their habits.

EEGER acute stroke study »

Principal Investigator: Steven Cramer, MD

EMRAP Liaison(s): Christopher Lew, Jeffrey Liu

Purpose: The purpose of this study is to examine the utility of 2 new EEG systems (Cognionics & StatNET) for rapid assessment of patients with suspected stroke to allow for earlier diagnosis and treatment improvement.

Evaluation and investigation of drivers in motor vehicle collisions under the influence of drugs at an emergency department »

Principal Investigator: Bharath Chakravarthy, MD, MPH

EMRAP Liaison(s): Mincy Chakkalakal

Purpose: The purpose of this study is to compare urine toxicology data with serum toxicology data in drivers involved in motor vehicle accidents, which will help to identify the at-risk population in Orange county through a prospective analysis of 900 motor vehicle victims that arrive at UCIMC.

How an educational program on emergency department expectations affects patient satisfaction »

Principal Investigator: Shannon Toohey, MD

EMRAP Liaison(s): Jasmina Dukovic

Purpose: To see if an education video shown upon arrival to the ED can improve patient satisfaction.

Incidence of distraction in trauma »

Principal Investigator: Shahram Lotfipour, MD, MPH

Co-Investigator: Cristobal Barrios MD, FACS

EMRAP Liaison: Brittany Le

Purpose: To determine whether Distraction is equally as dangerous to pedestrians, bicyclist and other forms of transportation.

Knowledge retention of opioid education in emergency department patients using a multimedia platform »

Principal Investigator: Bharath Chakravarthy, MD, MPH

EMRAP Liaison: Shashank Soma

Purpose: To measure knowledge retention of opioid analgesics safety through a multimedia presentation for patients who are prescribed opioid analgesics in the adult ED. Having established feasibility in the previous stage, this stage seeks to understand whether or not patients better retain information dispensed through a multimedia platform better than the current standard of care. 

Methods and evaluation of an emergency-department-based naloxone distribution program »

Principal Investigator(s): Bharath Chakravarthy, MD, MPH

EMRAP Liaison(s): Shashank Soma

Purpose: This study intends to assess the implementation of a naloxone distribution program administered through the UC Irvine Emergency Department. Naloxone, a drug typically used to reverse respiratory depression, is being piloted for use outside the clinical setting by means of an auto-injector. 

National Emergency Airway Registry (NEAR) »

Principal Investigator: Erik Barton, MD, MS, MBA

Co-Investigators: Cassondra Majestic, MD

EMRAP Liaison(s): Dana Le

Purpose: The goal of the study is to collect self-reported data by the  physician pertaining to emergency intubation events such as patient vital signs, physical characteristics that classify the patient as a potential difficult airway, any drugs administered, intubation devices used, the confirmation of intubation success, and number of intubation attempts. Data collected from the UCI Medical Center Emergency Department will be part of a national emergency airway management registry, National Emergency Airway Registry (NEAR). The database allows investigators the ability to examine multi-center intubation practices, as over 30 abstracts and manuscripts have utilized data drawn from NEAR.

Pilot study of the 360 degree perceptions of EM professionalism in western and eastern cultural context »

Principal Investigator: Wirachin Hoonpongsimanont, MD, MS

Co-Investigator: Khuansiri Narajeenron, MD

EMRAP Liaison(s): Jasmina Dukovic

Purpose: To explore and understand the disparities in the perception of EM professionalism among patients and health care providers in different cultures.

Procalcitonin antibiotic consensus trial (ProAct) »

Principal Investigator: Shahram Lotfipour, MD, MPH

EMRAP Liaison: Diveena Davis

Purpose: The objective of this study is to determine the efficacy of procalcitonin as a biomarker that enables physicians to differentiate between viral and bacterial respiratory infections. If determined to be an effective biomarker, procalcitonin could be used as a guide for when physicians decide to prescribe antibiotics or not. This could prevent unnecessary antibiotic presciptions that often have side effects and contribute to overall antibiotic resistance. The UC Irvine Medical Center Emergency Department (ED) is one of many research sites conducting this nationwide study.
Respiratory syncytial virus study »

Principal Investigator: Bharath Chakravarthy, MD, MPH

EMRAP Liaison(s): Micaela Sotelo

Purpose: To study the efficacy of an antiviral drug developed by Johnson & Johnson as a potential treatment for adult patients hospitalized and diagnosed with the Respiratory Syncytial virus (RSV).

StrokeApp: a comparative study »

Principal Investigator: Warren Wiechmann MD, MBA

Co-Investigator: Maxwell Jen, MD

EMRAP Liaison: Areeb Iqbal

Purpose: To compare NIHSS (National Institute Scale) measurement performance of stroke-certified ED RNs using StrokeApp vs. pen-paper.
Transport of low acuity EMS patients to alternate destinations. »

Principal Investigator: Shira A. Schlesinger, MD, MPH

EMRAP Liaison(s): Tracy Nguyen 

Purpose: The primary objective of this study is to assess the safety of Alternate Destination Paramedic Trainee (ADPT) evaluation and transport decision-making of select low acuity patients to Urgent Care Clinics instead of to Emergency Departments. Patients with designated low-acuity complaints who call 911 requesting evaluation and transport will be evaluated in the field by the ADPTs who have received additional training in screening for potential life or limb-threatening injury. Patients whom the ADPT deems appropriate for transport to Urgent Care will be offered enrollment in the program and will be consented for study participation.
Trauma CT occult injury yields, interventions, and outcomes »

Principal Investigator: Mark I. Langdorf, MD, MHPE

EMRAP Liaison(s): Bhavesh H. Patel

Purpose: Previous work has shown that computed tomography (CT) of the chest (CCT) identifies “occult” injuries not found on initial plain chest radiograph (CXR), and that 40.8% and 29.1% of patients with hemothorax and pneumothorax receive chest tube drainage, respectively. The utility of these chest tubes is questionable. We seek to determine if these are necessary by comparing output, duration, and length of stay (ICU and other) between chest tubes placed for CXR-identified PTX and HTX vs. CCT-only identified “occult” injuries. 

UC Irvine emergency department observation unit database »

Principal Investigator(s): Bharath Chakravarthy, MD, MPH

Co-Investigator(s): John Marshall, MD

EMRAP Liaison(s): Shashank Soma, Mina Ayad

Purpose: To assess the quality of patient stays in the EDOU and to ensure the protocol-driven discharge home of at least 80% of all patients within 24 hours. By creating a database with patient satisfaction and disposition information, we hope to answer research questions on the efficiency of EDOUs and its use in expediting patient care with limited resources. 

Ultrasonographic measurements of right ventricular outflow tract systolic excursion to diagnose patients with acute pulmonary thromboembolism: a comparison to the gold standard (RVOT) »

Principal Investigator: J. Christian Fox, MD

Co-Investigators: Candace Gutierrez, MD 

EMRAP Liaison(s): Shannon Lee, Amal Shafi 

Purpose: The purpose of this study is to determine if RSE (right ventricular systolic excursion) is highly sensitive and specific for patients with aPE, regardless of hemodynamic status, and compare it to the gold standard for diagnosing aPE, namely CTPA.

Use of ocular point of care ultrasound in diagnosing retinal detachment in the emergency department: a prospective study. »

Principal Investigator: John Christian Fox, MD, RMDS

Co-Investigators: Shadi Lahham, MD

EMRAP Liaisons: Bhavesh Patel, Tushank Chadha

Purpose: To determine if ED physicians are able to diagnosis ocular complaints, specifically retinal detachment, by using ultrasound.

Utilization of education videos to improve communication and discharge instructions, a quality improvement project »

Principal Investigator: Shannon Toohey, MD, MAEd

EMRAP Liaison: Rishi Gadepally

Purpose: The objective of this study is to determine if educational videos with discharge instructions provided in tandem with written instructions will improve patient understanding upon discharge

Validating¬†AUDIT¬†Using Serum Phosphatidylethanol¬†(PeTH) »

Principal Investigator(s): Wirachin Hoonpongsimanont, MD

Co-Investigator(s): Shahram Lotfipour, MD, MPH

EMRAP Liaison(s): Leila Danishgar, Osama Mobayed

Purpose: The VAUSP (Validating AUDIT Using Serum PeTH) study evaluates the usefulness of serum phosphatidyletanol (PeTH) protein biomarker by comparing the blood alcohol level to a survey-generated AUDIT score. The AUDIT score is retrieved from the Computerized Alcohol Screening and Intervention (CASI) survey. This study will focus on predicting whether PeTH is the best way to evaluate alcohol in the blood, and the validity of AUDIT in relation to PeTH.