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Current Research Studies

Alcohol risk assessment using computerized alcohol screening instrument in trauma patients »

Principal Investigator: Shahram Lotfipour, MD, MPH

EMRAP Liaison(s): Ghadi Ghanem

Purpose: To evaluate the alcohol consumption habits of trauma patients in the Emergency Department.

Ambulance diversion: a retrospective study »

Principal Investigator: Christopher McCoy, MD, MPH

Co-Investigator: Maxwell Jen, MD

EMRAP Liaison(s): Argineh Shahbandari, Mayuri Patel

Purpose: To analyze risk factors associated with ambulance diversion.

Andexanet alfa (annexa) potential reversal agent factor xa inhibitors: clinical trial study »

Principal Investigator: Shahram Lotfipour, MD, MPH

Co-Investigator: Rick Jones, CCRP

EMRAP Liaison(s): Leila Danishgar 

Purpose: To study the efficacy of Andexanet Alfa, a reversal anti-coagulant developed by Portola Pharmaceuticals. Specifically, we are looking at % change in anti-fXa activity, hemostatic efficacy in limited amount of time, and analyzing the relationship between decrease in anti-fXa and achievement of hemostatic efficacy

Assessing emergency department patient satisfaction: comparison between the Press Ganey and institution-implemented surveys »

Principal Investigator: Wirachin Hoonpongsimanont, MD

EMRAP Liaison(s): Christine Louis, Maria Nguyen

Purpose: To determine the accuracy of the Press Ganey survey and a shortened, institutional version of the survey in representing the views of a sample of UC Irvine Medical Center ED patients.

Clinical evaluation of tinnitus after head trauma in emergency setting. »

Principal Investigator: Yaser Ghavami, MD

EMRAP Liaison(s): Ryan Assaf

Purpose: The purpose of this research study is to determine the prevalence of acute and chronic tinnitus - the perception of sound without an external stimulus - in patients with a history of head trauma or traumatic brain injury. 

EEGER acute stroke study »

Principal Investigator: Steven Cramer, MD

EMRAP Liaison(s): Christopher Lew, Jeffrey Liu

Purpose: The purpose of this study is to examine the utility of 2 new EEG systems (Cognionics & StatNET) for rapid assessment of patients with suspected stroke to allow for earlier diagnosis and treatment improvement.

Efficacy of Trigger Point Injections in the Emergency Department for Myofascial Back and Neck Pain in Adults »

Principal Investigator: Bharath Chakravarthy, MD, MPH

EMRAP Liaison: Quan Lam

Evaluation and investigation of drivers in motor vehicle collisions under the influence of drugs at an emergency department »

Principal Investigator: Bharath Chakravarthy, MD, MPH

EMRAP Liaison(s): Mincy Chakkalakal

Purpose: The purpose of this study is to compare urine toxicology data with serum toxicology data in drivers involved in motor vehicle accidents, which will help to identify the at-risk population in Orange county through a prospective analysis of 900 motor vehicle victims that arrive at UCIMC.

How an educational program on emergency department expectations affects patient satisfaction »

Principal Investigator: Shannon Toohey, MD

EMRAP Liaison(s): Jasmina Dukovic

Purpose: To see if an education video shown upon arrival to the ED can improve patient satisfaction.

Incidence of distraction in trauma »

Principal Investigator: Shahram Lotfipour, MD, MPH

Co-Investigator: Cristobal Barrios MD, FACS

EMRAP Liaison: Brittany Le

Purpose: To determine whether Distraction is equally as dangerous to pedestrians, bicyclist and other forms of transportation.

Knowledge retention of opioid education in emergency department patients using a multimedia platform »

Principal Investigator: Bharath Chakravarthy, MD, MPH

EMRAP Liaison: Shashank Soma

Purpose: To measure knowledge retention of opioid analgesics safety through a multimedia presentation for patients who are prescribed opioid analgesics in the adult ED. Having established feasibility in the previous stage, this stage seeks to understand whether or not patients better retain information dispensed through a multimedia platform better than the current standard of care. 

Methods and evaluation of an emergency-department-based naloxone distribution program »

Principal Investigator(s): Bharath Chakravarthy, MD, MPH

EMRAP Liaison(s): Shashank Soma

Purpose: This study intends to assess the implementation of a naloxone distribution program administered through the UC Irvine Emergency Department. Naloxone, a drug typically used to reverse respiratory depression, is being piloted for use outside the clinical setting by means of an auto-injector. 

National Emergency Airway Registry (NEAR) »

Principal Investigator: Sangeeta Sakaria, MD, MPH, MST

Co-Investigators: Maxwell Jen, MD, MBA & Jessica Hoffmann, MD

EMRAP Liaison(s): Dana Le

Purpose: The goal of the study is to collect self-reported data by the  physician pertaining to emergency intubation events such as patient vital signs, physical characteristics that classify the patient as a potential difficult airway, any drugs administered, intubation devices used, the confirmation of intubation success, and number of intubation attempts. Data collected from the UCI Medical Center Emergency Department will be part of a national emergency airway management registry, National Emergency Airway Registry (NEAR). The database allows investigators the ability to examine multi-center intubation practices, as over 30 abstracts and manuscripts have utilized data drawn from NEAR.

Point-of-Care ultrasound measurement of carotid artery parameters compared to sphygmomanometer blood pressure measurement »

Principal Investigator: Alaina Brinely, MD, PhD

Co-Investigators: John Christian Fox, MD, RMDS and Shadi Lahham, MD

EMRAP Liaison(s): Michelle Bui, Shana Kong

Purpose: The purpose of the study is to find blood velocity and compliance of the carotid artery using point-of- care ultrasound, and use these measurements to derive a novel, efficient, and accurate method for obtaining patient blood pressure in an emergency setting.

Point-of-Care Ultrasound – Necrotizing Fasciitis »

Principal Investigator: Shadi Lahham, MD

Co-investigator: Inna Shiniter, MD

EMRAP Liaisons: Madeline Sands

Purpose: To determine if ED physicians are able to diagnose NSTI and its corresponding disposition to emergent surgical intervention

Respiratory syncytial virus study »

Principal Investigator: Bharath Chakravarthy, MD, MPH

EMRAP Liaison(s): Brittany Le

Purpose: To study the efficacy of an antiviral drug developed by Johnson & Johnson as a potential treatment for adult patients hospitalized and diagnosed with the Respiratory Syncytial virus (RSV).

The effect of a dedicated registered nurse case manager on the length of stay of behavioral health related visits in the emergency department »

Principal Investigator: Bharath Chakravarthy, MD, MPH

Co-Investigator: Chris Kim, MBS

EMRAP Liaison(s): Madeline Sands

Purpose: To identify if using a nurse case manager for psychiatric patients in the emergency department improves patient care when compared against no case manager or non-clinically trained case managers.

Trauma CT occult injury yields, interventions, and outcomes »

Principal Investigator: Mark I. Langdorf, MD, MHPE

EMRAP Liaison(s): Bhavesh H. Patel

Purpose: Previous work has shown that computed tomography (CT) of the chest (CCT) identifies “occult” injuries not found on initial plain chest radiograph (CXR), and that 40.8% and 29.1% of patients with hemothorax and pneumothorax receive chest tube drainage, respectively. The utility of these chest tubes is questionable. We seek to determine if these are necessary by comparing output, duration, and length of stay (ICU and other) between chest tubes placed for CXR-identified PTX and HTX vs. CCT-only identified “occult” injuries. 

Tricuspid Annular Plane Systolic Excursion (TAPSE) Assessment in Septic Cardiomyopathy »

Principal Investigator: Shadi Lahham, MD

Co-Investigator: Maxwell Thompson, MD

EMRAP Liaisons: Joseph Bui, Lisa Wang

Use of ocular point of care ultrasound in diagnosing retinal detachment in the emergency department: a prospective study. »

Principal Investigator: John Christian Fox, MD, RMDS

Co-Investigators: Shadi Lahham, MD MS

EMRAP Liaisons: Dana Le

Purpose: To determine if ED physicians are able to diagnose ocular complaints, specifically retinal detachment, by using point-of- care ultrasound.

Validating AUDIT Using Serum Phosphatidylethanol (PeTH) »

Principal Investigator(s): Wirachin Hoonpongsimanont, MD

Co-Investigator(s): Shahram Lotfipour, MD, MPH

EMRAP Liaison(s): Ghadi Ghanem, Christine Louis, Maria Nguyen

Purpose: The VAUSP (Validating AUDIT Using Serum PeTH) study evaluates the usefulness of serum phosphatidyletanol (PeTH) protein biomarker by comparing the blood alcohol level to a survey-generated AUDIT score. The AUDIT score is retrieved from the Computerized Alcohol Screening and Intervention (CASI) survey. This study will focus on predicting whether PeTH is the best way to evaluate alcohol in the blood, and the validity of AUDIT in relation to PeTH.